Protein Details: Amiloride-sensitive sodium channel subunit alpha
Protein ID
ICDB_Pro_0153
Protein Name
Amiloride-sensitive sodium channel subunit alpha
Gene Name
SCNN1A
Organism
Anolis carolinensis (Green anole) (American chameleon)
Length
636 amino acids
AlphaFoldDB
AF-H9GBX2-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus.
Sequence
MKSENQPEDKRIGKLKREANMQKMKEAAEVEEKKKEENEALVGFFHSYQELFQFFCNNTTIHGAIRLVCSKKNRMKTAFWSILFFFTFGLMYWQFGIIYREYFSFPVNLNLNLNSDRFTFPAVTLCTLNPYRYSALQNELAELDHITQKTLMDLYKYDMSQGQNNRKAQLSRKRSYRSLHYHVSRHPLHRYKRDSQASIEDNNTQVDKNDWKIAFSVCNENNTDCFKQMYSSGVDAVREWYSFHYINILSRIPNAKSLDESDFASFIYACRFNEVTCDKANYTHFHHPIYGNCYTFNANSSNLWMSSLPGINNGLSLVVRTEQNDFIPLLSTVTGARVMVHNQNEPAFMDEGGFNVRPGIETSISMRKETTNRLGGTYSDCTEDGSDVPVKNLYTSRYTEQVCIRSCFQNSIVERCGCGHYFYPLPSGAVYCDYAKHKAWGYCYYKLLAEFKADLLGCFTKCRKPCKVTEYQLSAGYSRWPSTASEAWVFHILSRQNQYNITSKRNGVAKVNIFFEQWNHKSNGESPAFTVVTLLSQLGSQWSLWFGSSVLSVVELVELILDFIAITCILAIHWLNMNRSSDLPIPTSNTTDTFHNVLPPPNTLPRASVDPDVITLPSYKSLESLDLRRVSSQQTE
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1038/nature10390
RefSeq
XP_003226512.1